Moreover, like any tool, statistical methods can be misused. Of course, the use of statistical synthesis methods does not guarantee that the results of a review are valid, any more than it does for a primary study. Statistical synthesis of findings allows the degree of conflict to be formally assessed, and reasons for different results to be explored and quantified. To settle controversies arising from apparently conflicting studies or to generate new hypotheses.It may also, if relevant, allow reasons for differences in effect estimates to be investigated. A selection of studies in which these characteristics differ can allow investigation of the consistency of effect across a wider range of populations and interventions. Primary studies often involve a specific type of participant and explicitly defined interventions.
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